Reconstructive Transplantation Research Award

 
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    CFDA#

    12.420     		 

    Funder Type

    Federal Government

    IT Classification

    B - Readily funds technology as part of an award

    Authority

    U.S. Department of Defense (DOD)

    Summary

    This program seeks to fund innovative projects that have the potential to make a significant impact on improving the function, wellness, and overall quality of life for injured military Service Members and Veterans, their caregivers and family members, and the American public. It challenges the scientific community to design innovative research that will foster new directions for and address neglected issues in the field of reconstructive transplantation (RT), specifically vascularized composite allotransplantation (VCA)-focused research, also known as composite tissue allotransplantation (CTA). Focus areas include:
    • Immune Rejection
      • Understanding mechanisms of immune rejection
      • Immunomodulation approaches and mechanisms, e.g., tolerance induction, chimerism
      • Optimizing immunosuppressive drug regimens
    • Tissue Preservation
      • Understanding mechanisms of ischemic and/or reperfusion injury in composite tissue grafts
      • Prolonging allograft preservation
      • Mitigating ischemic injury
    • Graft Surveillance-Clinical Monitoring
      • Histopathology
      • Imaging
      • Immune profiling, e.g., gene expression, graft rejection markers, cytokine screens
      • Vasculopathy
    • RT Recipient Outcomes
      • Rehabilitation to improve transplant function
      • Patient selection criteria as correlates to VCA outcomes
      • National shared data repository
    • Standardization of Processes and Protocol
      • Collaboration in clinical protocol standardization, which may include endpoint selection, assay selection, and functional outcomes measures
      • Techniques for tracking long-term outcomes
      • Standardization of procedures for pathology
    • Unique Focus Area
      • Describe how the work is applicable to research for the injured military and/or Veteran population requiring RT of the face and extremities to include genitourinary injuries of both men and women.
     

    History of Funding

    None is available.

    Additional Information

    Applications from investigators within the military Services and applications involving multidisciplinary collaborations among academia, industry, the military Services, the Department of Veterans Affairs (VA), and other Federal Government agencies are highly encouraged. Though this program supports groundbreaking research, all projects must demonstrate solid scientific rationale with military-relevant utility.

    Contacts

    CDMRP Help Desk

    CDMRP Help Desk
    U.S. Department of Defense
    Department of the Army
    1077 Patchel Street
    Fort Detrick, MD 21702-5024
    (301) 682-5507
     

  • Eligibility Details

    Eligible applicants include:

    • Independent investigators at all academic levels (or non-academic equivalent)
    • Organizations: national, international, for-profit, non-profit, public, private

    Deadline Details

    Applications must be submitted October 29, 2014, by 11:59 p.m. Eastern Daylight Time (EDT).

    Award Details

    The estimated funding available for FY14 is $13,300,000. Preclinical studies have a funding ceiling of $750,000. Clinical research/clinical trials have a funding ceiling of $2,000,000. The maximum project period is 4 years. Cost sharing/matching is not required.

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