Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development for Disorders of the Nervous System (U44)

 
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    CFDA#

    93.853, 93.273, 93.242, 93.213, 93.279, 93.865, 93.121     		 

    Funder Type

    Federal Government

    IT Classification

    B - Readily funds technology as part of an award

    Authority

    U.S. Department of Health and Human Services (HHS), National Institutes of Health (NIH)

    Summary

    This program seeks to discover and develop small molecule compounds, of a size and structure that can be readily synthesized and chemically modified (if optimization is required). This program is not designed to support development of biologics or biotechnology products, including oligonucleotides and proteins, or devices. There are two stages within the program: the Discovery stage and the Development stage.
    • Discovery: to optimize well-validated hit compounds through medicinal chemistry
    • Development: advance development candidates through Investigational New Drug (IND)-enabling toxicology studies and Phase I clinical testing 

    Projects not appropriate for this program include:

    • Screening to identify hit compounds
    • Basic research and studies of disease mechanism
    • Animal model development
    • Development of risk, detection, diagnostic, prognostic, predictive, and prevention biomarkers
    • Development of diagnostics and diagnostic devices
    • Development of biologics and biotechnology products
    • Studies directed beyond Phase I clinical testing
     

    History of Funding

    None is available. 

    Additional Information

    Multiple institutes have interests in this program and offer specific areas of study. They are:
    • National Institute on Aging (NIA): provide drug development expertise and infrastructure support to researchers interested in developing new small molecules aimed at modifying the behavioral symptoms in Alzheimer's disease (AD), delaying the onset or slowing the progression of AD, mild cognitive impairment (MCI), other dementias of aging and age-related cognitive decline 
    • National Institute on Alcohol Abuse and Alcoholism (NIAAA): interested in research aimed to develop pharmaceuticals targeting new molecular sites to provide effective therapy to a broader spectrum of alcoholic individuals 
    • National Institute of Dental and Craniofacial Research (NIDCR): interested in neurotherapeutics development for chronic painful disorders of the orofacial region including temporomandibular joint disorder, burning mouth syndrome, and other conditions 
    • National Institute of Mental Health (NIMH): interested in applications proposing development of therapies aimed at novel molecular and clinical targets for the treatment of mental disorders, especially treatment-resistant depression, bipolar disorder, schizophrenia, PTSD, and autism spectrum disorder 
    • National Institute of Neurological Disorders and Stroke (NINDS): the discovery and development of small molecule drugs
    • National Center for Complementary and Alternative Medicine (NCCAM): interested in supporting research aimed at naturally occurring compounds (e.g., cannabinoids, venoms, conotoxins) that may be used or developed to modulate CNS-based symptoms with priority given to pain and pain related symptoms

    Contacts

    Tijuanna E. DeCoster, Ph.D.

    Tijuanna E. DeCoster, Ph.D.
    U.S. Department of Health and Human Services
    National Institute of Neurological Disorders and Stroke (NINDS)
    NSC BG RM 3258
    6001 Executive Blvd Mail Stop: 9537
    Rockville, MD 20852
    (301) 496-9231
    (301) 402-0219
     

  • Eligibility Details

    Only U.S. small business concerns (SBCs) are eligible to submit applications for this opportunity. 

    Deadline Details

    All non-AIDS applications are due by 5:00 p.m. local time of applicant organization on the following dates: October 21, 2014; February 11, 2015; August 11, 2015; February 11, 2016; August 11, 2016; February 8, 2017. 

    All AIDS applications are due by 5:00 p.m. local time of applicant organization on the standard due dates.

    Award Details

    Application budgets are not limited but need to reflect the actual needs of the proposed project. The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. Applicants should rarely exceed up to $400,000 total cost for Phase I and up to $4,000,000 total cost for Phase II, A duration of 1 year is expected for Phase I and up to 3 years for Phase II. Cost sharing/matching is not required. 

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